Polycythemia vera complicated by IgA nephropathy: A case report and literature review

Abstract

Polycythemia vera (PV)-associated kidney disease is rare in clinical practice, and its complexity and low incidence pose challenges for clinicians. This report presents a case from our center highlighting the treatment process and prognosis, which may provide valuable insights for future clinical management. This case involves a male patient primarily exhibiting proteinuria. Through laboratory tests and examinations, he was diagnosed with PV complicated by immunoglobulin A nephropathy. His treatment included hydroxyurea and erythrocytapheresis to reduce erythrocyte count, sacubitril/valsartan to address hypertension and proteinuria, and appropriate symptomatic treatment. After treatment, the patient has been regularly monitored, and his condition is now under control, with proteinuria resolving. Given the rare presentation of such diseases, it is easy to overlook their associations, which complicates their clinical diagnosis and treatment. Therefore, further exploration of this condition’s diagnostic and treatment processes and prognosis is warranted.